MAPS
1 / 7
Colour
The predictions and interpretations from this tool are computational hypotheses generated by machine learning models.They should not be treated as clinical diagnoses or used as the sole basis for medical decisions.
Each point is one missense variant. Coordinates come from running ESM-C (6B) on the mutant protein sequence and reading the layer-78 embedding at the mutated residue, then projecting those high-dimensional vectors to 2D with UMAP. Variants that land near each other have similar ESM-C representations.
Colour encodes the property chosen in the header, read as the wild-type → mutant disruption at that residue — not the residue's absolute value.